Statistical analysis of DNA mixtures with artefacts

by Therese Graversen

DNAmixtures is a statistical framework for analysis of DNA samples from one or multiple donors. DNAmixtures implements a statistical model described in a recent paper, Analysis of Forensic DNA mixtures with Artefacts, that is published with discussion in Journal of the Royal Statistical Society, series C.

Screenshot of DNAmixtures in the R GUI
Common forensic applications
Computation of likelihood ratios
Deconvolution of the DNA mixture
Combined analysis of multiple traces of DNA
Visual assessment of the statistical modelling
Does the hypothesis explain the data well?
Is the distribution of peak heights adequate?
Efficient exact computation
Runs on a standard desktop or laptop
Allows a higher number of contributors
A complete statistical framework
Exact computation of the likelihood function
Maximum likelihood estimation of parameters
Simulation of genotypes and peak heights
Access to various conditional distributions of peak heights given data

System requirements

DNAmixtures may be installed on any system (Windows, Linux, or MacOS), on which the following three programs are installed:

RStatistical software
HuginBayesian network software
RHuginAPI for calling Hugin from within R

DNAmixtures can be installed and loaded from R by:

install.packages("DNAmixtures", repos = "http://dnamixtures.r-forge.r-project.org/",
type = "source", INSTALL_opts = "--no-multiarch")

For further details on installation, see the Installation page.

Questions and comments are very welcome and can be directed to the author, Therese Graversen.